The 7th Annual Meeting on High Performance Computing and Infrastructure in Norway

NOTUR2008 - ABSTRACTS

The thermolysin family of enzymes:cold adaptatino and inhibition interactions

Olayiwola Adekoya

Zinc containing peptidases are widely distributed in nature and have important roles in many physiological processes. The thermolysin family of enzymes (M4 family) is zinc-dependent metallopeptidases that hydrolyze peptide bonds.  A large number of these enzymes are implicated as virulence factors of the microorganisms that produce them and are therefore potential drug targets. Furthermore, enzymes in the family are also adapted to function at the extremes of temperatures or in organic solvents, and thereby have an innovative potential for biotechnological applications.

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